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Medetomidine HRP Conjugate
Product key features
- Selective Detection – Enables specific recognition of medetomidine in competitive ELISA formats using anti-medetomidine antibodies.
- High Enzymatic Activity – HRP retains strong catalytic function, allowing sensitive detection via chromogenic, chemiluminescent, or fluorogenic substrates.
- Covalent Conjugation – Medetomidine is covalently linked to HRP to ensure stability and consistent performance across assays.
- Optimized for Immunoassays – Ideal for pharmacokinetic and bioanalytical applications involving medetomidine detection in biological samples.
- Reproducible Results – Provides low background, high signal-to-noise ratios, and reliable batch-to-batch consistency.
Product description
Medetomidine HRP Conjugate is a horseradish peroxidase-labeled derivative of medetomidine, a potent and selective α2-adrenergic receptor agonist widely utilized in veterinary medicine and neuroscience research. This conjugate is specifically designed for use in competitive enzyme-linked immunosorbent assays (ELISAs) and related immunoassay platforms to facilitate the sensitive and quantitative detection of medetomidine in biological matrices such as plasma, serum, or tissue extracts. The medetomidine moiety is covalently linked to horseradish peroxidase via optimized conjugation chemistry to preserve both the antigenic recognition by anti-medetomidine antibodies and the enzymatic activity of HRP. In competitive assay formats, the HRP-conjugated medetomidine competes with free analyte for binding to a limited amount of immobilized antibody, allowing for inverse correlation between signal intensity and analyte concentration. The conjugate provides high signal-to-noise ratios and robust batch-to-batch consistency, making it well-suited for pharmacokinetic profiling, drug monitoring, and analytical applications requiring high specificity and reproducibility.
References
View all 16 references: Citation Explorer
An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice.
Authors: Tanaka, Shuto and Kawakita, Masataka and Yasui, Hikaru and Sudo, Koichi and Itoh, Fumie and Sasaki, Masato and Shibata, Nobuyuki and Hara, Hiromitsu and Iwakura, Yoichiro and Hashidate-Yoshida, Tomomi and Shindou, Hideo and Shimizu, Takao and Oyama, Taiki and Matsunaga, Himawari and Takahara, Kazuhiko
Journal: Communications biology (2024): 782
Authors: Tanaka, Shuto and Kawakita, Masataka and Yasui, Hikaru and Sudo, Koichi and Itoh, Fumie and Sasaki, Masato and Shibata, Nobuyuki and Hara, Hiromitsu and Iwakura, Yoichiro and Hashidate-Yoshida, Tomomi and Shindou, Hideo and Shimizu, Takao and Oyama, Taiki and Matsunaga, Himawari and Takahara, Kazuhiko
Journal: Communications biology (2024): 782
Contribution of UGT Enzymes to Human Drug Metabolism Stereoselectivity: A Case Study of Medetomidine, RO5263397, Propranolol, and Testosterone.
Authors: Milani, Nicolò and Qiu, NaHong and Fowler, Stephen
Journal: Drug metabolism and disposition: the biological fate of chemicals (2023): 306-317
Authors: Milani, Nicolò and Qiu, NaHong and Fowler, Stephen
Journal: Drug metabolism and disposition: the biological fate of chemicals (2023): 306-317
Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis.
Authors: Sandbaumhüter, Friederike A and Vimercati, Sara and Thormann, Wolfgang and Mevissen, Meike
Journal: Toxicology in vitro : an international journal published in association with BIBRA (2018): 242-248
Authors: Sandbaumhüter, Friederike A and Vimercati, Sara and Thormann, Wolfgang and Mevissen, Meike
Journal: Toxicology in vitro : an international journal published in association with BIBRA (2018): 242-248
Blood acid-base status in impala (Aepyceros melampus) immobilised and maintained under total intravenous anaesthesia using two different drug protocols.
Authors: Zeiler, Gareth E and Meyer, Leith C R
Journal: BMC veterinary research (2017): 246
Authors: Zeiler, Gareth E and Meyer, Leith C R
Journal: BMC veterinary research (2017): 246
Effects of medetomidine and its active enantiomer dexmedetomidine on N-demethylation of ketamine in canines determined in vitro using enantioselective capillary electrophoresis.
Authors: Sandbaumhüter, Friederike A and Theurillat, Regula and Thormann, Wolfgang
Journal: Electrophoresis (2015): 2703-2712
Authors: Sandbaumhüter, Friederike A and Theurillat, Regula and Thormann, Wolfgang
Journal: Electrophoresis (2015): 2703-2712
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