Purified Anti-human CD11b Antibody *HI11b*
HI11b is an anti-human monoclonal antibody that recognizes the CD11b antigen. CD11b (sometimes referred to as Integrin αM chain, C3biR, CR3A or CR3) is a 165 - 170 kD glycoprotein that is expressed on the surface of cells such as B cells, granulocytes, NK cells, macrophages and dendritic cells. CD11b is involved with important cellular pathways, in particular, the cytokine-mediated signaling pathway, toll-like receptor 4 signaling pathway and apoptotic signaling pathway. Additionally, in many organisms, it is a promoter of superoxide anion generation, positively regulates microglial cell mediated cytotoxicity and is a positive regulator of prostaglandin-E synthase activity. CD11b has been associated with critical biological processes like cell adhesion, specifically cell-cell adhesion via plasma-membrane adhesion molecules, and is associated with a variety of biologically interesting macromolecules/ligands, for example, Factor X, iC3b and ICAM-1. CD11b is a very popular antibody target, with over 45000 publications in the last decade. CD11b has been widely used in innate immunity, neuroscience cell markers and cell biology research, often serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of cd11b antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Page updated on October 11, 2024