Purified Anti-human CD45 Antibody *HI151*

HI151 is an anti-human monoclonal antibody that targets the CD45 antigen. CD45 (also known as Leukocyte Common Antigen (LCA) or PTPRC) is a 180 - 240 kD transmembrane protein that is expressed on the surface of cells like B cells, macrophages, granulocytes and NK cells. CD45 has been associated with essential biological processes like dephosphorylation, specifically protein dephosphorylation. Also, in some organisms, it plays a role in the upregulation of stem cell proliferation, is an inhibitor of cytokine-mediated signaling pathway and enhances hematopoietic stem cell migration. CD45 acts in vital cellular pathways, for example, the B cell receptor signaling pathway, positive regulation of antigen receptor-mediated signaling pathway and negative regulation of cytokine-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands like Src kinases. CD45 is a very popular antibody target, with over 50000 publications in the last decade. CD45 is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, particularly in the study of cell biology and neuroscience. This antibody was purified through affinity chromatography.