Purified Mouse Anti-human Cytokeratin 18 Antibody *AHC0095, Monoclonal, lgG2b, kappa*

Purified Mouse Anti-human Cytokeratin 18 Antibody

AHC0095, Monoclonal, lgG2b, kappa

Keratin, type I cytoskeletal 18 is a 56 kDa protein that can be found in the nucleolus, cytoplasm and microtubule organizing center of cells. It is sometimes referred to as cell proliferation-inducing gene 46 protein, Keratin-18 or Cytokeratin-18. In Homo sapiens, keratin, type I cytoskeletal 18 recognizes scaffold protein, cadherin involved in cell-cell adhesion and RNA. It is an integral part of organismal processes, for example, intermediate filament cytoskeleton organization, anatomical structure morphogenesis and Golgi to plasma membrane CFTR protein transport. It is the subject of intensive study stemming from the fact that it is a member of the extrinsic apoptotic signaling pathway and tumor necrosis factor-mediated signaling pathway. Sequencing of Keratin, type I cytoskeletal 18 has shown evidence that it contains a primary structural unit, the IF rod domain. It has been closely linked to essential functions like structural molecule activity. Keratin, type I cytoskeletal 18 is a negative regulator of apoptotic process. Mutations and abnormalities in Keratin, type I cytoskeletal 18 have been associated with a number of diseases, for example, Cirrhosis (CIRRH).

General packaging for catalog V104090. Actual shipped packaging may vary.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
V104090	100 μg / 100 μl	Price

Conjugation

We provide custom conjugation services for this antibody (e.g. labeling of Cytokeratin 18 antibody with HRP). A list of available labels can be found in the table below:

Label Type	Available Labels
AF	AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750
Proteins	HRP, Alkaline Phosphatase, Streptavidin
Tandems	APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5
Small Molecules	Biotin
Traditional Dyes	FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5
iFluor	350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7
mFluor	UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780

For additional information about custom conjugations, please consult our services page

here

Antibody properties

Clone	AHC0095
Host	mouse
Isotype	lgG2b, kappa
Reactivity	human
Application	IHC

Storage, safety and handling

Intended use

Research Use Only (RUO)

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Page updated on August 5, 2024