AAT Bioquest

Purified Mouse Anti-human Ep-CAM/Epithelial Specific Antigen Antibody *AHC0106, Monoclonal, IgG1, kappa*

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Intended useResearch Use Only (RUO)


Other names
IgG1, kappa
Epithelial cell adhesion molecule is a transmembrane protein with a molecular weight of 35 kDa, expressed in the bicellular tight junction, apical plasma membrane and extracellular exosome of cells. It is sometimes referred to as cell surface glycoprotein trop-1, epithelial glycoprotein (Ep-CAM) and KS 1/4 antigen. In humans, epithelial cell adhesion molecule aids in organismal processes, for example, leukocyte migration, ureteric bud development and stem cell differentiation. Sequencing of epithelial cell adhesion molecule has exemplified it contains 3 conserved structural units: extracellular, cytoplasmic and thyroglobulin type-1 domain. Epithelial cell adhesion molecule aids in signal transduction involved in gene expression. It recognizes protein-containing complex and cadherin involved in cell-cell adhesion. It positively regulates cell motility, stem cell proliferation and cell population proliferation while also is involved in the negative regulation of cell-cell adhesion mediated by cadherin and apoptotic process. Mutations and abnormalities in epithelial cell adhesion molecule have been associated with a number of diseases, for instance, diarrhea 5 (DIAR5) and hereditary non-polyposis colorectal cancer 8 (HNPCC8). Diarrhea 5 with congenital tufting enteropathy, an autosomal recessive inheritancedisorder characterized by small for gestational age, Intractable diarrhea and villous atrophy, has especially been of interest to investigators.


We provide custom conjugation services for this antibody (eg. labeling of Ep-CAM/Epithelial Specific Antigen antibody with HRP). A list of available labels can be found in the table below:

AFAF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750
ProteinsHRP, Alkaline Phosphatase, Streptavidin
TandemsAPC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5
Small MoleculesBiotin
Traditional DyesFITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5
iFluor350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7
mFluorUV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780

For additional information about custom conjugations, please consult our services page here.