Name: ReadiUse™ probenecid *25 mM stabilized aqueous solution*
Brand: AAT Bioquest
SKU: 20062
Price: 178 USD
Availability: InStock

ReadiUse™ probenecid

25 mM stabilized aqueous solution

ReadiUse™ Probenecid is a stabilized aqueous solution of probenecid, an organic anion transporter inhibitor used to improve intracellular retention of fluorescent indicators in cell-based assays.

Transporter inhibition: Inhibits organic anion transporters that can extrude fluorescent indicators from cells
Improved dye retention: Helps reduce leakage of intracellular fluorescent indicators and lower assay background
Ready-to-use aqueous format: Supplied as a stabilized water-soluble solution, avoiding the need to dissolve free acid probenecid with NaOH
Research applications: Suitable for calcium indicator loading, calcium flux assays, and other live-cell fluorescence assays requiring improved dye retention

Chemical structure for ReadiUse™ probenecid *25 mM stabilized aqueous solution*

Datasheet

SDS

Catalog	Size	Price	Quantity
20062	10x10 mL	Price

Overview

ReadiUse™ Probenecid is a stabilized aqueous solution of probenecid designed to improve intracellular retention of fluorescent indicators in live-cell assays. Probenecid inhibits organic anion transporters located in cell membranes, which can otherwise pump fluorescent dye indicators out of cells and contribute to poor dye retention and increased assay background.

The free acid form of probenecid has poor solubility in neutral aqueous solutions and typically requires dissolution with NaOH before use. ReadiUse™ Probenecid provides a convenient water-soluble format that is easier to incorporate into assay workflows. The 25 mM solution can be diluted into assay buffer, with a 1:10 dilution producing a commonly used final probenecid concentration of 2.5 mM. ReadiUse™ Probenecid is suitable for calcium flux assays, fluorescent indicator loading workflows, and other cell-based fluorescence assays that require improved intracellular dye retention.

Citations

View all 13 citations: Citation Explorer

Optimization of Magnetoelectric Nanoparticles for Applications in Cancer Theranostics

Authors:

Shotbolt, Max

Translational selenium nanomedicine synergizes with nab-paclitaxel to enhance antitumor effects in esophageal squamous cell cancer via selenoprotein N-mediated ER stress

Authors:

Huang, Haoyang and Liu, Shaowei and Xu, Ligeng and Liang, Hengrui and Wu, Zihao and Chen, Tianfeng and Wang, Jinlin and Liu, Jun

Journal:

Journal of Nanobiotechnology (2025): 294

Mitochondrial-dependent oxidative phosphorylation is key for postnatal metabolic adaptation of alveolar macrophages in the lung

Authors:

Zhang, Jun and Peng, Yu and Song, Haosen and Liu, Siqi and Li, Chuanwei and Zhang, Yi and Shi, Xiaowei and Guo, Huifang and Xu, Yingping

Journal:

International Immunopharmacology (2024): 112012

Magnetic-field-synchronized wireless modulation of neural activity by magnetoelectric nanoparticles

Authors:

Zhang, E and Abdel-Mottaleb, M and Liang, P and Navarrete, B and Yildirim, Y Akin and Campos, M Alberteris and Smith, IT and Wang, P and Yildirim, B and Yang, L and others,

Journal:

Brain Stimulation (2022): 1451--1462

Pharmacogenomic screening of drug candidates using patient-specific hiPSC-derived cardiomyocyte high-throughput calcium imaging

Authors:

Blancard, Malorie and Fetterman, K Ashley and Burridge, Paul W

References

View all 35 references: Citation Explorer

DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833

Authors:

Myllynen P, Kurttila T, Vaskivuo L, Vahakangas K.

Journal:

Toxicol Lett (2007): 3

Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists

Authors:

Tahara H, Kusuhara H, Chida M, Fuse E, Sugiyama Y.

Journal:

J Pharmacol Exp Ther (2006): 1187

Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid

Authors:

Tahara H, Kusuhara H, Maeda K, Koepsell H, Fuse E, Sugiyama Y.

Journal:

Drug Metab Dispos (2006): 743

MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid

Authors:

Huisman MT, Chhatta AA, van Tellingen O, Beijnen JH, Schinkel AH.

Journal:

Int J Cancer (2005): 824

Mediation of annexin 1 secretion by a probenecid-sensitive ABC-transporter in rat inflamed mucosa

Authors:

Wein S, Fauroux M, Laffitte J, de Nadai P, Guaini C, Pons F, Comera C.

Journal:

Biochem Pharmacol (2004): 1195

Physical properties

Molecular weight	307.34
Solvent	Water

Usage and storage

Intended use	Research Use Only (RUO)
Storage	Freeze (< -15 °C); Minimize light exposure

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Page updated on September 14, 2026