Salinomycin-HRP conjugate

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Physical properties

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Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Overview SDS Protocol

Salinomycin is a polyether monocarboxylic acid produced by Streptomyces albus. It is used in the prevention of coccidiosis in poultry caused by E. necatrix, E. tenella, E. acervulina, E. brunette, E. maxima, and E. mivati. Salinomycin is active against certain Gram-positive bacteria, whereas Enterobacteriaceae are resistant. Salinomycin also has an inhibitory effect on Clostridium perfringens, thus the use of salinomycin leads to a decrease in the incidence of necrotic enteritis in broiler chickens. Salinomycin is considered as the marker residue and skin/fat as the target tissue. Salinomycin produces relatively low residue levels in the eggs compared with other polyether ionophores. Salinomycin-HRP conjugate is an essential reagent for quantifying Salinomycin by ELISA.

Images

Figure 1. Chemical structure for Salinomycin-HRP conjugate.

References

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Facile fabrication of a novel 3D rose like lanthanum doped zirconia decorated reduced graphene oxide nanosheets: An efficient electro-catalyst for electrochemical reduction of futuristic anti-cancer drug salinomycin during pharmacokinetic study [Biosens Bi
Authors: Alkahtani, Saad A and Mahmoud, Ashraf M and Mahnashi, Mater H and Ali, Ramadan and El-Wekil, Mohamed M
Journal: Biosensors & bioelectronics (2021): 113202

Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.
Authors: Burke, Ryan M and Dirkx, Ronald A and Quijada, Pearl and Lighthouse, Janet K and Mohan, Amy and O'Brien, Meghann and Wojciechowski, Wojciech and Woeller, Collynn and Phipps, Richard P and Alexis, Jeffrey D and Ashton, John and Small, Eric M
Journal: Circulation research (2021)

Ester derivatives of salinomycin efficiently eliminate breast cancer cells via ER-stress-induced apoptosis.
Authors: Kuran, Dominika and Flis, Sylwia and Antoszczak, Michał and Piskorek, Marlena and Huczyński, Adam
Journal: European journal of pharmacology (2021): 173824

Simultaneous immunodetection of ionophore antibiotics, salinomycin and narasin, in poultry products and milk.
Authors: Burkin, Maksim A and Galvidis, Inna A
Journal: Analytical methods : advancing methods and applications (2021): 1550-1558

Keratin nanoparticles and photodynamic therapy enhance the anticancer stem cells activity of salinomycin.
Authors: Avancini, Greta and Guerrini, Andrea and Ferroni, Claudia and Tedesco, Daniele and Ballestri, Marco and Columbaro, Marta and Menilli, Luca and Reddi, Elena and Costa, Roberto and Leanza, Luigi and Varchi, Greta and Moret, Francesca
Journal: Materials science & engineering. C, Materials for biological applications (2021): 111899

Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells.
Authors: Wang, Qin and Yen, Ying-Tzu and Xie, Chen and Liu, Fangcen and Liu, Qin and Wei, Jia and Yu, Lixia and Wang, Lifeng and Meng, Fanyan and Li, Rutian and Liu, Baorui
Journal: Drug delivery (2021): 510-519

Effects of supplementation with narasin, salinomycin, or flavomycin on performance and ruminal fermentation characteristics of Bos indicus Nellore cattle fed with forage-based diets.
Authors: Limede, Arnaldo Cintra and Marques, Rodrigo S and Polizel, Daniel Montanher and Cappellozza, Bruno Ieda and Miszura, Alexandre Arantes and Barroso, José Paulo Roman and Storti Martins, André and Sardinha, Lairana Aline and Baggio, Marcelo and Pires, Alexandre Vaz
Journal: Journal of animal science (2021)

In Vitro Antiviral Activities of Salinomycin on Porcine Epidemic Diarrhea Virus.
Authors: Yuan, Chen and Huang, Xintong and Zhai, Ruiyu and Ma, Yichao and Xu, Anyuan and Zhang, Penghao and Yang, Qian
Journal: Viruses (2021)

Low-dose salinomycin inhibits breast cancer metastasis by repolarizing tumor hijacked macrophages toward the M1 phenotype.
Authors: Shen, Huan and Sun, Changquan Calvin and Kang, Lichun and Tan, Xiaoyue and Shi, Peng and Wang, Lingyu and Liu, Ergang and Gong, Junbo
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2021): 105629

Role of a Two-Component Signal Transduction System RspA1/A2 in Regulating the Biosynthesis of Salinomycin in Streptomyces albus.
Authors: Zhang, Kuipu and Mohsin, Ali and Dai, Yichen and Ali, Muhammad Fahad and Chen, Zhongbing and Zhuang, Yingping and Chu, Ju and Guo, Meijin
Journal: Applied biochemistry and biotechnology (2021): 1296-1310