Salinomycin-KLH conjugate

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Physical properties

Molecular weight	N/A
Solvent	Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Overview SDS Protocol

Molecular weight

N/A

Salinomycin is a polyether monocarboxylic acid produced by Streptomyces albus. It is used in the prevention of coccidiosis in poultry caused by E. necatrix, E. tenella, E. acervulina, E. brunette, E. maxima, and E. mivati. Salinomycin is active against certain Gram-positive bacteria, whereas Enterobacteriaceae are resistant. Salinomycin also has an inhibitory effect on Clostridium perfringens, thus the use of salinomycin leads to a decrease in the incidence of necrotic enteritis in broiler chickens. Salinomycin is considered as the marker residue and skin/fat as the target tissue. Salinomycin produces relatively low residue levels in the eggs compared with other polyether ionophores. Salinomycin-KLH conjugate is used for developing and screening Salinomycin antibodies.

Images

Figure 1. Chemical structure for Salinomycin-KLH conjugate.

References

View all 20 references: Citation Explorer

Molecular characterization and functional analysis of Eimeria tenella citrate synthase.
Authors: Wang, Haixia and Zhao, Qiping and Zhu, Shunhai and Dong, Hui and Yu, Shuilan and Wang, Qingjie and Yu, Yu and Liang, Shanshan and Zhao, Huanzhi and Huang, Bing and Han, Hongyu
Journal: Parasitology research (2021): 1025-1035

Molecular characterization and analysis of the ATPase ASNA1 homolog gene of Eimeria tenella in a drug sensitive strain and drug resistant strains.
Authors: Yu, Yu and Dong, Hui and Zhao, Qiping and Zhu, Shunhai and Liang, Shanshan and Wang, Qingjie and Wang, Haixia and Yu, Shuilan and Huang, Bing and Han, Hongyu
Journal: International journal for parasitology. Drugs and drug resistance (2021): 115-125

Targeted Delivery of Combination Therapeutics Using Monoclonal Antibody 2C5-Modified Immunoliposomes for Cancer Therapy.
Authors: Narayanaswamy, Radhika and Torchilin, Vladimir P
Journal: Pharmaceutical research (2021): 429-450

Enhanced targeting of prostate cancer-initiating cells by salinomycin-encapsulated lipid-PLGA nanoparticles linked with CD44 antibodies.
Authors: Wei, Jun and Sun, Jin and Liu, Yu
Journal: Oncology letters (2019): 4024-4033

Vasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer.
Authors: Hori, Ami and Shimoda, Masafumi and Naoi, Yasuto and Kagara, Naofumi and Tanei, Tomonori and Miyake, Tomohiro and Shimazu, Kenzo and Kim, Seung Jin and Noguchi, Shinzaburo
Journal: Breast cancer research : BCR (2019): 88

The enhanced delivery of salinomycin to CD133+ ovarian cancer stem cells through CD133 antibody conjugation with poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles.
Authors: Mi, Yi and Huang, Yuqin and Deng, Jie
Journal: Oncology letters (2018): 6611-6621

Promoted delivery of salinomycin sodium to lung cancer cells by dual targeting PLGA hybrid nanoparticles.
Authors: Zhou, Jie and Sun, Jin and Chen, Huaiwen and Peng, Qing
Journal: International journal of oncology (2018): 1289-1300

Combination of drug-conjugated SWCNT nanocarriers for efficient therapy of cancer stem cells in a breast cancer animal model.
Authors: Al Faraj, Achraf and Shaik, Asma Sultana and Ratemi, Elaref and Halwani, Rabih
Journal: Journal of controlled release : official journal of the Controlled Release Society (2016): 240-51

CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel.
Authors: Muntimadugu, Eameema and Kumar, Rajendra and Saladi, Shantikumar and Rafeeqi, Towseef Amin and Khan, Wahid
Journal: Colloids and surfaces. B, Biointerfaces (2016): 532-546

Laser-induced fluorescence reader with a turbidimetric system for sandwich-type immunoassay using nanoparticles.
Authors: Kim, Y H and Lim, H B
Journal: Analytica chimica acta (2015): 32-6