Tide Quencher™ 4WS-DBCO [TQ4WS-DBCO]

Tide Quencher™ 4WS-DBCO

TQ4WS-DBCO

TQ4WS is designed to be a superior quencher to ROX, TF4, iFluor® 594, Alexa Fluor® 594 and Texas Red®. TQ4WS has (a). much stronger absorption; (b). much higher quenching efficiency; and (c). versatile reactive forms with desired solubility for labeling oligonucleotides and peptides. This TQ4WS-DBCO product is reactive to azides under copper-free conditions, and useful for click chemistry. DBCO is probably the most common alkyne among the strain promoted alkyne-azide cycloaddition (SPAAC), which is also termed as the Cu-free click reaction. Cyclooctynes and azides exclusively and efficiently react with each other while remain inert to naturally occurring functional groups such as amines. SPAAC enables labeling a wide variety of biomolecules without any auxiliary reagents in an aqueous and otherwise complex chemical environment through the formation of a stable triazole. DBCO (dibenzocyclooctynes) compounds comprise a class of reagents that possesses reasonably fast kinetics and good stability in aqueous buffers. Within physiological temperature and pH ranges, the DBCO group will not react with amines or hydroxyls that are naturally present in many biomolecules. Additionally, reaction of the DBCO group with the azide group is significantly faster than with sulfhydryl groups (–SH, thiol).

Protocol

SDS

COA

Catalog	Size	Price	Quantity
2070	1 mg	Price

References

View all 50 references: Citation Explorer

pH-Triggered Copper-Free Click Reaction-Mediated Micelle Aggregation for Enhanced Tumor Retention and Elevated Immuno-Chemotherapy against Melanoma.

Authors:

Deng, Miao and Guo, Rong and Zang, Shuya and Rao, Jingdong and Li, Mengmeng and Tang, Xian and Xia, Chunyu and Li, Man and Zhang, Zhirong and He, Qin

Journal:

ACS applied materials & interfaces (2021): 18033-18046

Cytosolic protein delivery via metabolic glycoengineering and bioorthogonal click reactions.

Authors:

Zhao, Ziyin and Zhang, Zhimin and Duan, Shanzhou and Liu, Xun and Zhou, Renxiang and Hou, Mengying and Sang, Yonghua and Zhu, Rongying and Yin, Lichen

Journal:

Biomaterials science (2021): 4639-4647

Cancer cell-targeted cisplatin prodrug delivery in vivo via metabolic labeling and bioorthogonal click reaction.

Authors:

Liu, Xun and Wu, Fan and Cai, Kaimin and Zhao, Ziyin and Zhang, Zhimin and Chen, Yongbing and Liu, Yong and Cheng, Jianjun and Yin, Lichen

Journal:

Biomaterials science (2021): 1301-1312

Interventional nuclear medicine: "click" chemistry as an in vivo targeting strategy for imaging microspheres and bacteria.

Authors:

Welling, M M and Duszenko, N and van Willigen, D M and Hensbergen, A W and Buckle, T and Rietbergen, D D D and Roestenberg, M and van Leeuwen, F W B

Journal:

Biomaterials science (2021): 1683-1690

In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry.

Authors:

Kwon, Soonmin and Choi, Hyunsu and Park, Changhee and Choi, Sangkee and Kim, Eunha and Kim, Sung Won and Kim, Choung-Soo and Koo, Heebeom

Journal:

Biomaterials science (2021): 108-115

Physical properties

Molecular weight	1158.49
Solvent	DMSO

Spectral properties

Absorbance (nm)	605
Correction factor (260 nm)	0.149
Correction factor (280 nm)	0.136
Extinction coefficient (cm ^-1 M ^-1)	90000 ¹

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on October 23, 2025