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Are there any alternatives to indocyanine green (ICG)?

Posted August 12, 2021


Answer

Brilliant blue green (BBG), infracyanine green (IfCG), and bromophenol blue (BPB) are three vital dyes that have been used as alternatives to ICG during chromovitrectomy. 

Another alternative to ICG is iFluor® 790. iFluor® 790 is the brightest near-IR dye available that is spectrally similar to indocyanine green (ICG), Alexa Fluor® 790, and IRDye® 800 dye. The excellent water-solubility and salt tolerance, pH-insensitive fluorescence and photostable signal generation of iFluor® 790 dye is superior for high density labeling applications, Western blotting and immunocytochemical (ICC) assays, as well as for protein arrays, microscopy, in vivo imaging and IR optical probe development. iFluor® 790 is favorable for small animal in vivo imaging applications or for other imaging applications that require NIR detections such as the two-color western applications with the LI-COR® Odyssey® infrared imaging system.

 

Additional resources

Comparative in vitro safety analysis of dyes for chromovitrectomy: indocyanine green, brilliant blue green, bromophenol blue, and infracyanine green

ICG Xtra-OSu

iFluor™ 790-streptavidin conjugate