AAT Bioquest

Does BrdU (Bromodeoxyuridine) trigger cell death?

Posted September 9, 2021


Yes, BrdU (Bromodeoxyuridine) triggers cell death. BrdU is a cytotoxic, teratogenic, and mutagenic substance. It triggers several adverse effects on the cell including altering the stability of DNA, the formation of teratomas, lengthening of the cell cycle, and cell death. In addition, cells that incorporate BrdU have mitogenic, transcriptional, and translational effects on cells.

Additional resources

Cytotoxic and genotoxic effects of bromodeoxyuridine during in vitro labelling for sister-chromatid differentiation in preimplantation mouse embryos

Cell Meter™ Colorimetric Cell Cytotoxicity Assay Kit

Apoptosis and Necrosis