AAT Bioquest

How does ATP activate the inflammasome?

Posted October 13, 2021


In the event of a bacterial infection or sterile tissue injury, host immune cells release ATP (adenosine triphosphate) as an inflammatory signal. ATP then acts via a feedback mechanism on the P2X7 channel to induce NLRP3 inflammasome activation and subsequently process and release interleukin (IL)-18.

Additional resources

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

PhosphoWorks™ Luminometric ATP Assay Kit *Steady Glow*