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AAT Bioquest

What are the main building blocks of peptidoglycan?

Posted July 1, 2021


Answer

Amino sugars and tetrapeptides form the building blocks of peptidoglycan. Each peptidoglycan molecule consists of two amino sugars, N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM). These molecules are alternated in long chains and cross-linked to one another by a tetrapeptide coming off the NAM sugar. Interlocking chains of identical peptidoglycan monomers form a vast polymer that makes up the peptidoglycan layer, which surrounds the outside of the cytoplasmic membrane of bacterial cell walls.

Additional resources

Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan

Gram Staining