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Are inflammasomes and caspase-1 related?

Posted October 15, 2021


Answer

Yes, inflammasomes and caspase-1 are related.

The formation of inflammasomes is a key event in the innate immune response to certain inflammatory stimuli. Inflammasomes are multimeric protein complexes that regulate the activation of caspase-1, which is the central protease in this response. Caspase-1 subsequently leads to the maturation of the proinflammatory cytokines and to pyroptosis, a form of cell death that is induced by bacterial pathogens.

Additional resources

The Inflammasome: A Caspase-1 Activation Platform Regulating Immune Responses and Disease Pathogenesis

Caspases

Z-IETD-pNA *CAS 219138-21-3*