What is whole genome sequencing (WGS) used for?

Whole-genome sequencing (WGS) is a comprehensive method for analyzing entire genomes in a single experiment. The high resolution, base-by-base view of the entire genome allows researchers to determine the complete DNA sequence including the coding and noncoding regions of an organism. WGS has a wide range of applications including but not limited to:

• Identifying inherited disorders in newborns
• Tracking disease outbreaks
• Tailoring disease treatments to an individual’s genetic makeup
• Identifying how genetic variation influences transcription
• Characterizing the mutations that drive cancer progression
• Studying the whole genomes of rare types of cancers
• Detecting variants contributing to disease in a family with segregating alleles
• Performing large-scale, longitudinal studies of complex traits, which are crucial for identifying underlying genetics