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What methods are best for inhibiting intracellular calcium release?
Posted May 9, 2020
Answer
To inhibit intracellular calcium release, you can use BAPTA-AM or EGTA-AM, which are both calcium ion chelators. Other options are xestospongin C, an IP3 inhibitor; U-73122, a phospholipase C inhibitor; and GF109302X, a protein kinase C inhibitor.
Additional resources
Lin, B. H., Tsai, M. H., Lii, C. K., & Wang, T. S. (2016). IP3 and calcium signaling involved in the reorganization of the actin cytoskeleton and cell rounding induced by cigarette smoke extract in human endothelial cells. Environmental toxicology, 31(11), 1293-1306. Amplite® Colorimetric Calcium Quantitation Kit *Blue Color*Screen Quest™ Fluo-8® No Wash Calcium Assay KitBAPTA, AM *UltraPure Grade*EGTA, AM *10 mM DMSO Solution*