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AAT Bioquest

Do lyases and ligases require external energy sources for their catalytic activities?

Posted March 26, 2024


Answer

Only ligases require external energy sources for their catalytic activities. The energy required to drive the formation of covalent bonds is typically derived from hydrolysis of ATP

Lyases do not require any external energy source for their catalytic activities. 

Additional resources

Exploring the Biological and Chemical Complexity of the Ligases

Enzymes

Peptide and Protein Molecular Weight Calculator