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AAT Bioquest

How do I quantify the basicity of amines?

Posted May 17, 2024


Answer

To quantify the basicity of amines, one should look at the pKa of its conjugate acid. The higher the pKa of the conjugate acid, the stronger the base. In contrast, the lower the pKa of the conjugate acid, the weaker the base.

Additional resources

Basicity of Amines

Intracellular pH

Weak Base pH Calculator