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AAT Bioquest

What are the advantages of click chemistry?

Posted April 10, 2024


Answer

Two key advantages are that click reactions typically proceed rapidly and with high selectivity, yielding desired products efficiently. Another advantage is that click reactions occur under mild conditions, such as room temperature and aqueous environments like water, minimizing the need for harsh reaction conditions. Additionally, these reactions are bio-orthogonal and can often be performed selectively in the presence of other functional groups. Click chemistry can be applied to a wide range of substrates and functional groups, making it highly versatile for diverse applications. These reactions also offer ease of purification, are simple in nature, and have the ability to precisely position components (regiospecificity) and yield high product quantities. 

Additional resources

Click Chemistry

Click Chemistry