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AAT Bioquest

How does click chemistry work?

Posted April 10, 2024


Answer

Click reactions take place in a single container, generate minimal and harmless byproducts and are not influenced by water. They proceed irreversibly, producing a single product with precise specificity. Described as "spring-loaded," click reactions possess a robust driving force, ensuring efficient conversion to the desired product. Achieving this high energy state in the reactants can be challenging, often requiring methods such as utilizing light as a stimulus or using oxidation reactions.

Additional resources

Click Chemistry, a Powerful Tool for Pharmaceutical Sciences

Click Chemistry

FastClick™ Cy3 Azide