Label-free immunoassays offer several significant advantages over labeled techniques. 

• Designing and developing the assay are simpler, cheaper, and faster as modified substrates or components are not required. 
• Reagent preparation is also faster, simpler and cheaper.
• Biomolecular interactions can be observed and studied under conditions similar to the native state allowing for deeper characterization of biological interactions.
• Label-free eliminates the risk of interference from secondary reporters and reagents, resulting in more robust assay signals.