AAT Bioquest

What are the benefits of having peptide bonds?

Posted March 21, 2023


Peptide bonds make proteins the most stable polymers. All organisms go through proteolysis, which is the hydrolysis of a peptide bond by attacking the carbonyl group of a peptide chain. These bonds can survive hours in harsh environmental conditions like a boiling acidic environment, but under proteases they quickly are broken. Peptide bonds are essential to the human body as they are responsible for holding amino acids together, forming long chains. Without them, amino acids would not be able to join one another and proteins could not be properly formed. The result of the attachment of amino acids is a planar structure which is stabilized by resonance between the a-amino and a-carboxyl groups. This planar trans configuration undergoes very little rotation and twisting, providing high durability and stability for polymers.

Additional resources

The Shape and Structure of Proteins