What are the common classes of hydrolases?

Question

Accepted Answer

Hydrolases are classified as EC 3 in the ‘Enzyme Commission’ number classification of enzymes. This is a numerical system of classifying enzymes and is based on the bonds that the hydrolases act on.

Classes of hydrolases

Bonds that are hydrolyzed

EC 3.1

Ester bonds, e.g. lipase, phosphatase, phosphodiesterase, nuclease, etc.

EC 3.2

Glycosidic bonds, e.g. DNA glycosylases, glycoside hydrolase, amylase, maltase, etc.

EC 3.3

Ether bonds

EC 3.4

Peptide bonds, e.g. pepsin, trypsin, proteases, peptidases, chymotrypsin, etc.

EC 3.5

Carbon-nitrogen bonds, other than peptide bonds, e.g urease, etc.

EC 3.6

Acid anhydrides, e.g. helicases, hydrolases, GTPase, etc.

EC 3.7

Carbon-carbon bonds

EC 3.8

Halide bonds

EC 3.9

Phosphorus-nitrogen bonds

EC 3.10

Sulfur-nitrogen bonds

EC 3.11

Carbon-phosphorus bonds

EC 3.12

Sulfur-sulfur bonds

EC 3.13

Carbon-sulfur bonds

Classes of hydrolases	Bonds that are hydrolyzed
EC 3.1	Ester bonds, e.g. lipase, phosphatase, phosphodiesterase, nuclease, etc.
EC 3.2	Glycosidic bonds, e.g. DNA glycosylases, glycoside hydrolase, amylase, maltase, etc.
EC 3.3	Ether bonds
EC 3.4	Peptide bonds, e.g. pepsin, trypsin, proteases, peptidases, chymotrypsin, etc.
EC 3.5	Carbon-nitrogen bonds, other than peptide bonds, e.g urease, etc.
EC 3.6	Acid anhydrides, e.g. helicases, hydrolases, GTPase, etc.
EC 3.7	Carbon-carbon bonds
EC 3.8	Halide bonds
EC 3.9	Phosphorus-nitrogen bonds
EC 3.10	Sulfur-nitrogen bonds
EC 3.11	Carbon-phosphorus bonds
EC 3.12	Sulfur-sulfur bonds
EC 3.13	Carbon-sulfur bonds

What are the common classes of hydrolases?

Posted January 22, 2024