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How does the induced fit model work?
Posted January 22, 2024

Answer

The induced fit model describes enzymes as relatively flexible structures that have the ability to alter the shape at the active site to complement that of the substrate.  

According to this model, in the unbound state, the shape of the enzyme’s active site is not complementary to the substrate. During the interactions between the active site and the substrate, several factors influence the structural configuration of the enzyme’s active site and induce it to assume a shape complementary to the substrate so that there is a precise fit between the active site and the substrate. 

The influencing factors that induce a change in the active site of the enzyme include pH, coenzymes, temperature, lipid binding, ionic strength, and enzymatic modification.