What are the cons of ultracentrifugation for exosome isolation?
Posted July 21, 2023
Ultracentrifugation for exome isolation involves subjecting a sample to high centrifugal forces to separate exosomes from other cellular components based on their size and density.
Cons of ultracentrifugation:
- Procedure is relatively complex and time-consuming
- Requires specialized high-speed centrifuge instrument that is expensive and not readily available
- Excessively high centrifugal forces and repetitive processes can potentially alter the structure of or damage exosomes