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What are the differences between autolysis and apoptosis?
Posted April 13, 2023
ApoptosisApoptosis and NecrosisCell Viability AssaysCellular ProcessesEnzymes
Answer

Basis of differentiation

Autolysis

Apoptosis

Definition
Autolysis is the destruction of an organism’s cells by enzymes created by the cells themselves (especially those released by lysosomes) 
A programmed form of cell death in which cells undergo an ordered sequence of events which causes its death
Occurrence
Autolysis does not occur in healthy tissues
Apoptosis occurs in healthy tissue frequently 
Intentionality
Autolysis is unintentional
Apoptosis is intentional
Effect
Results in harmful effects on surrounding tissues or cells
Does not produce harmful substances that interfere with (when undergoing the process properly) 
Regulation
Is not a regulated process
Is a controlled process 
Mechanism
Occurs because of lysosomal enzymes
Cells undergo changes like cellular blebbing, nuclear fragmentation, cell shrinkage, chromatin condensation, chromosomal DNA fragmentation, and mRNA decay
Type of organism exists in
Occurs in both multicellular and unicellular organisms
Occurs in multicellular organisms
Additional resources
Autolysis Cell Meter™ Phosphatidylserine Apoptosis Assay Kit *Blue Fluorescence Optimized for Microplate Readers*

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