Basis of differentiation | Bulk sequencing | Single cell RNA-seq |
Definition | Sequencing library represents a population of cells | Sequencing library represents a single cell |
Output type | Measures average expression level across a cell population | Provides more detailed information on individual cells |
Complexity level | Quicker and less complex analysis | More complex analysis |
Expression | Information on heterogeneity of the cell population is unavailable | Provides information on heterogeneity of cell populations and subpopulation expression |
Time | Less time-consuming | More time-consuming |
Labor | Less laborious | Labor intensive |
Cost | Less expensive | More expensive |