Basis of differentiation | Krebs cycle | Glycolysis |
Definition | Refers to a series of chemical reactions in which pyruvate is converted to acetyl-CoA and is completely oxidized to carbon dioxide and water - also known as the citric acid cycle or tricarboxylic acid cycle (TCA cycle) | Refers to the series of chemical reaction in which a glucose molecule is degraded and broken down into two pyruvate (pyruvic acid) molecules |
Order of occurrence | Is the second step of cellular respiration | Is the first step of cellular respiration |
Place of occurence | Occurs in the mitochondria of eukaryotes | Occurs in the cytoplasm |
Aerobic/Anaerobic Respiration | Occurs only in aerobic respiration | occurs in aerobic and anaerobic respiration |
Oxygen requirement | Oxygen is used as terminal oxidant | Is not required |
Oxidative Phosphorylation | Is connected with the oxidative phosphorylation | Is not connected with the oxidative phosphorylation |
Process | Oxidizes pyruvate into carbon dioxide and water | Degrades glucose into two pyruvate molecules |
Pathway | Cyclic pathway | Linear pathway |
ATP consumption | Does not consume ATP | Consumes 2 ATP molecules |
Net gain | 6 NADH molecules and 2 FADH2 molecules are produced | 2 ATP molecules, 2 Pyruvate molecules, and 2 NADH molecules are produced |
Net gain of energy | Net energy gain is equal to 24 ATP molecules | Net energy gain is equal to 8 ATP molecules |
Carbon dioxide | Carbon dioxide is released | No carbon dioxide is released |
End product | Is an inorganic carbon substance | Is an organic substance |