What are the differences between Krebs cycle and glycolysis?
Posted March 30, 2023
Basis of differentiation |
Krebs cycle |
Glycolysis |
Definition |
Refers to a series of chemical reactions in which pyruvate is converted to acetyl-CoA and is completely oxidized to carbon dioxide and water - also known as the citric acid cycle or tricarboxylic acid cycle (TCA cycle) |
Refers to the series of chemical reaction in which a glucose molecule is degraded and broken down into two pyruvate (pyruvic acid) molecules |
Order of occurrence |
Is the second step of cellular respiration |
Is the first step of cellular respiration |
Place of occurence |
Occurs in the mitochondria of eukaryotes |
Occurs in the cytoplasm |
Aerobic/Anaerobic Respiration |
Occurs only in aerobic respiration |
occurs in aerobic and anaerobic respiration |
Oxygen requirement |
Oxygen is used as terminal oxidant |
Is not required |
Oxidative Phosphorylation |
Is connected with the oxidative phosphorylation |
Is not connected with the oxidative phosphorylation |
Process |
Oxidizes pyruvate into carbon dioxide and water |
Degrades glucose into two pyruvate molecules |
Pathway |
Cyclic pathway |
Linear pathway |
ATP consumption |
Does not consume ATP |
Consumes 2 ATP molecules |
Net gain |
6 NADH molecules and 2 FADH2 molecules are produced
|
2 ATP molecules, 2 Pyruvate molecules, and 2 NADH molecules are produced |
Net gain of energy |
Net energy gain is equal to 24 ATP molecules |
Net energy gain is equal to 8 ATP molecules |
Carbon dioxide |
Carbon dioxide is released |
No carbon dioxide is released |
End product |
Is an inorganic carbon substance |
Is an organic substance |
Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
Amplite® Colorimetric Pyruvate Assay Kit
Amplite® Fluorimetric Coenzyme A Quantitation Kit *Green Fluorescence*