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What are the differences between myeloblast and lymphoblast?
Posted March 5, 2024
Antibodies and Proteomics BioconjugationAntibody and Protein LabelingB CellsCD4+ T CellsCellular Processes
Answer
Basis of differentiation 
Myeloblast 
Lymphoblast 
Definition 
immature blood cells produced in bone marrow serves as the precursor of myelocytes
immature blood cells produced in bone marrow that serves as the precursor of lymphocytes
Diameter 
20 µm
15 µm
Presence of granules
Contains granules in the cytoplasm 
Cytoplasmic granules are absent
Shape of the nucleus
Nucleus may be S, C or V-shaped
Nucleus is rounded
Nucleoli 
The nucleus has a prominent nucleoli 
The nucleus has less distinct nucleoli 
Chromatin condensation
Chromatin is less condensed
Chromatin is highly condensed
Differentiate into 
  • Basophils
  • Neutrophils
  • Eosinophils
  • T lymphocytes
  • B lymphocytes
Pathology 
Dysfunction can cause acute myeloblastic  leukemia  (AML)
Dysfunction can cause acute lymphoblastic  leukemia (ALL)
Additional resources
The non-erythroid myeloblast count rule in myelodysplastic syndromes: fruitful or futile?Cluster of Differentiation (CD Antibodies) PE/Texas Red® Anti-human CD4 Antibody *RPA-T4*

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