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AAT Bioquest

What are the functions of macrophages?

Posted March 5, 2024


Answer

Macrophages carry out various functions in the human immune system including: 

  • Detection, phagocytosis and destruction of bacteria and other harmful microorganisms
  • Maintaining homeostasis by clearing out debris, and old, senescent, or dead cells 
  • Mediating reparative processes including muscle repair, growth, and regeneration after inflammation
  • Initiating inflammation by releasing small signaling proteins called anti-inflammatory cytokines that activate other immune cells
  • Presenting antigens to T cells 
  • Facilitating wound healing by limiting the extent of inflammation and contributing to tissue repair and regeneration
  • Maintaining iron homeostasis by acting as scavengers and continuously clearing out dead erythrocytes from blood, which leads to the accumulation of released iron in the form of ferritin
Additional resources

Macrophages: shapes and functions

CD4 (Leu3, T4)

PE/Texas Red® Anti-human CD4 Antibody *RPA-T4*