Basis of differentiation 

Paracrine signaling

Autocrine signaling

Definition

Paracrine signaling is when a cell signals to its adjacent cells using chemical messengers 

Autocrine signaling refers to a cell signaling itself using chemical messengers

Target cells

Targets the adjacent cells

Target the cells of production; itself

Signaling molecules

Neurotransmitters and hormones are the signaling molecules

Cytokines and growth factors are the main types of signaling molecules involved

Significance

Signal transmission occurs through the synaptic gap during paracrine signaling; important for cell communication and development 

Is involved in cell differentiation during early embryo development to ensure cells grow into tissue and have correct function