AAT Bioquest

What are the differences between primary and secondary lysosomes?

Posted November 30, 2022

Primary LysosomesSecondary Lysosomes
Primary lysosomes are membrane-bound organelles containing acid hydrolase enzymes, and bud from the Golgi apparatusSecondary lysosomes are formed by the fusion of a primary lysosome and an endosome
Smaller in size Larger in size
Do not go through digestion Go through digestion
Have inactive digestive enzymes in the form of granules Have functioning digestive enzymes
Are unable to dispose their content to the outside of the cellCan dispose their content to the outsite of the cell
Additional resources

Lysosomal physiology

Cell Navigator® Lysosome Staining Kit *Deep Red Fluorescence*