What are the differences between Receptor tyrosine kinasesand non-receptor tyrosine kinase?
Posted September 27, 2023
Answer
Basis of differentiation |
RTK |
NRTK |
Definition |
Is a subclass of tyrosine kinases which are involved in regulating cell-to-cell interactions and mediating different biological functions |
NRTKs are involved in signal transduction derived from extracellular cues, and normally interact with transmembrane receptors |
Structure |
RTKs consist of a single transmembrane domain |
NRTKs do not have a transmembrane domain or an extracellular ligand-binding domain |
Activation |
RTKs become activated via ligand-induced dimerization, initiating autophosphorylation |
NRTKs do not require ligand-induced dimerization,and are instead activated by heterologous protein-protein interactions to induce kinase phosphorylation |
Additional resources
Physiology, Tyrosine Kinase Receptors