Basis of differentiation

RTK

NRTK

Definition

Is a subclass of tyrosine kinases which are involved in regulating cell-to-cell interactions and mediating different biological functions

NRTKs are involved in signal transduction derived from extracellular cues, and normally interact with transmembrane receptors

Structure

RTKs consist of a single transmembrane domain

NRTKs do not have a transmembrane domain or an extracellular ligand-binding domain 

Activation

RTKs become activated via ligand-induced dimerization, initiating autophosphorylation 

NRTKs do not require ligand-induced dimerization,and are instead activated by heterologous protein-protein interactions to induce kinase phosphorylation