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AAT Bioquest

What are the examples of complement proteins found in the body?

Posted February 1, 2024


Answer

The complement system involves various proteins (from C1 to C9), factors B,D, H, I, and P, and mannose-binding lectin. C1-C9 are the nine major complement proteins. Properdin (factor P) functions to activate the alternative pathway C3 convertase enzyme. Factors B and D, which are also involved in the alternative pathway, are crucial components involved in complement activation. Factors H and I  help regulate the complement system by regulating the activation process. The MB-lectin pathway is activated when a protein called mannose-binding lectin (MBL) identifies specific carbohydrate patterns on pathogens, which then activates MBL-associated serine proteases (MASPs) to cleave C4 and C2.

Additional resources

Complement system

Antibodies and Proteomics

iFluor® 488 PSA™ Imaging Kit with Goat Anti-Mouse IgG