The induced fit model explains how the active site of enzymes undergoes conformational changes to facilitate a precise fit with the substrate.
Limitations of induced fit model include:
Does not factor in the chemistry of catalytic reactions, which may involve several chemical factors such as the potential presence of proton donors and receptors and electrostatic interactions
Does not fully describe structural transformations for very flexible proteins, including domain rearrangements, backbone collective movements, and disorder-to-order transition