What are the limitations of an induced fit model?

The induced fit model explains how the active site of enzymes undergoes conformational changes to facilitate a precise fit with the substrate. 

Limitations of induced fit model include:

• Does not factor in the chemistry of catalytic reactions, which may involve several chemical factors such as the potential presence of proton donors and receptors and electrostatic interactions
• Does not fully describe structural transformations for very flexible proteins, including domain rearrangements, backbone collective movements, and disorder-to-order transition