AAT Bioquest

What are the pros of the baculovirus expression system?

Posted August 5, 2023


Baculovirus expression systems have a large capacity. This means they have the ability to carry out large gene fragments, which is useful in large protein expression experiments. It is able to amplify and generate recombinant proteins on a large scale. Baculovirus expression systems have strict species specificity. Additionally, it possesses high expression efficiency. Proteins can be efficiently expressed in late-stage infected cells. Another advantage is that the post-translational modification of the expression product is similar to that of mammalian cells. Thus the protein is more likely to be bioactive.        

Additional resources

The baculovirus expression vector system: A commercial manufacturing platform for viral vaccines and gene therapy vectors

Antibodies and Proteomics