AAT Bioquest

What are the similarities between phosphorylation and dephosphorylation?

Posted February 10, 2023


Phosphorylation and dephosphorylation are two types of enzyme catalyzing reactions that involve phosphate groups. They are counterparts of each other. Both reactions are reversible and occur at specific sites on the surface of a protein. Both, phosphorylation and dephosphorylation, are important posttranslational modifications of native proteins, and both play key roles in intracellular signal transduction cascades and switching the enzymatic activity.

Additional resources

Phosphorylation, Dephosphorylation, and Multiprotein Assemblies Regulate Dynamic Behavior of Neuronal Cytoskeleton: A Mini-Review