What is the significance of ATP hydrolysis?

ATP hydrolysis provides energy for many different vital processes in cells and organisms. More specifically, it has roles in intracellular signaling, RNA and DNA synthesis, synaptic signaling, active transport, muscle contraction, and Puringeric signaling. Signal transduction is heavily dependent on ATP, as it serves as a substrate for kinases. ATP also assists as a trigger of intracellular messengers release. These messengers include various enzymes, hormones, lipid mediators, neurotransmitters, growth factors, nitric oxide, and reactive oxygen species. Purinergic signaling is mediated by ATP. ATP is released from vesicular sacs and regulated by IP3 molecules. ATP is also necessary for muscle contraction, as it pumps calcium ions across the sarcoplasmic reticulum. ATP also assists in the active transport of sodium and potassium ions across sarcolemma. ATP hydrolysis generates the energy necessary for these processes. ATP is also required for DNA and RNA synthesis. It is one of the 4 nucleotide-triphosphate monomers necessary during RNA synthesis. ATP hydrolysis has a wide role in many processes in the body and without it cells would not have the energy that is necessary for their survival.