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AAT Bioquest

Where does polymerization of actin occur?

Posted November 1, 2022


Answer

Polymerization of actin occurs primarily at or in close proximity to the plasma membrane. As a result, a region with a high density of actin filament is usually present at the cell cortex or cell periphery. Polymerization occurs at the plus-end of the actin filament. This is a reversible process with the monomers associating and dissociating from the ends of the filaments. Actin polymerization occurs over three phases – a nucleation phase, which involves the formation of a stable actin nucleus, an elongation phase, in which monomers are rapidly added to the filament at the positive end, and a steady state phase, during which the filament dynamics enter a state of equilibrium. 

Additional resources

Plasma Membrane

Cell Navigator® Cell Plasma Membrane Staining Kit *Green Fluorescence*

Role of Actin Polymerization in Cell Locomotion: Molecules and Models

Cell Navigator® F-Actin Labeling Kit *Blue Fluorescence*