APC Anti-human CD340 Antibody *24D2*

24D2 is an anti-human monoclonal antibody that targets the CD340 antigen. CD340 (alternatively called ERBB2 or HER-2) is a 185 kD transmembrane glycoprotein that is found on the surface of cells such as epithelial cells. CD340 has been closely linked to key biological processes like signal transduction, especially intracellular signal transduction. Furthermore, in certain organisms, it is an enhancer of cell growth, is an enhancer of GTPase activity and plays a role in the upregulation of translation. CD340 is a member of important cellular pathways, for example, the cell surface receptor signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway and negative regulation of ERBB signaling pathway. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands such as EGFR. CD340 is a relatively rare antibody target, with fewer than 100 publications in the last decade. Even still, CD340 is often used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of synaptic biology and immunology. This antibody was purified through affinity chromatography and conjugated to APC (ex/em = 651/660 nm). It is compatible with the 642 nm laser and 664/20 nm bandpass filter (for example, as in the Luminex Guava easyCyte).