APC Anti-non-human primates/ human CD177 Antibody *MEM-166*

MEM-166 is an anti-non-human primates/ human monoclonal antibody that targets the CD177 antigen. CD177 (sometimes referred to as Neutrophil-specifi c antigen 1, PRV1 or NB1gp) is a 60 kD member of the uPAR family that is expressed on the surface of cells like granulocytes. CD177 plays a role in critical cellular pathways, namely, the regulation of integrin-mediated signaling pathway. In addition, it has been associated with vital biological processes such as leukocyte cell-cell adhesion, particularly cell-cell adhesion via plasma-membrane adhesion molecules. In some organisms, CD177 is an enhancer of superoxide anion generation, and is associated with a variety of biologically interesting macromolecules/ligands. CD177 is a relatively rare antibody target, with fewer than 600 publications in the last decade. Even still, CD177 is essential for immunology research, typically serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to APC (ex/em = 651/660 nm). It is compatible with the 642 nm laser and 702/85 nm bandpass filter (for example, as in the Luminex Amnis ImageStream).