APC Anti-non-human primates/ human CD49b Antibody *AK7*

The AK7 monoclonal antibody reacts with non-human primates/ human CD49b, a 170 kD member of the Integrin alpha chain family commonly located on the surface of activated T cells, B cells and monocytes. In some organisms, CD49b plays a role in the upregulation of alkaline phosphatase activity, is involved in the positive regulation of translation and is a promoter of epithelial cell migration. Additionally, it plays a role in essential cellular pathways, for example, the integrin-mediated signaling pathway and collagen-activated signaling pathway. CD49b has been associated with critical biological processes such as cell adhesion, specifically cell adhesion mediated by integrin, and is associated with a variety of biologically interesting macromolecules/ligands, for example, laminin, collagen and MMP-1. CD49b is a fairly uncommon antibody target, with a little more than 3000 publications in the last decade. Even still, CD49b is commonly used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of immunology. This antibody was purified through affinity chromatography and conjugated to APC (ex/em = 651/660 nm). It is compatible with the 642 nm laser and 664/20 nm bandpass filter (for example, as in the Luminex Guava easyCyte).