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Biotin-PEG2-azide
CAS 945633-30-7
Biotin-PEG2-Azide CAS 945633-30-7 is a non-cleavable, azide-activated biotinylation reagent designed for use in bioconjugation applications. It selectively reacts with terminal alkynes to form stable triazole linkages, either via copper-catalyzed click reactions or Cu-free click reactions with strained cyclooctynes (e.g., DBCO or BCN compounds). Additionally, it can react with phosphine-labeled molecules through Staudinger chemistry. These reactions are bioorthogonal, meaning they do not interfere with biological systems. The inclusion of a hydrophilic PEG2 spacer in Biotin-PEG2-Azide enhances its aqueous solubility and reduces steric hindrance, particularly when binding to avidin molecules. This reagent is particularly useful for detecting cellular alkyne cholesterol analogs and for preparing multifunctional benzophenone linkers used in pull-down assays, photoaffinity labeling, and double-click stapling techniques.
Biotin-PEG2-Azide is an excellent alkyne-reactive building block for developing biotin probes in bioconjugation applications via the well-known click chemistry.
Biotin-PEG2-Azide is an excellent alkyne-reactive building block for developing biotin probes in bioconjugation applications via the well-known click chemistry.
CatalogSize
Price
Quantity
30255 mg
Price
 
Physical properties

Molecular weight400.50
SolventDMSO
Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Desiccated
UNSPSC12352200
CAS945633-30-7
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Page updated on October 13, 2025