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Biotin PEG4 amine

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Physical properties
Molecular weight418.55
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
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Molecular weight
Biotin PEG4 amine is a biotinylation reagent with a PEG4 spacer. It is an excellent building block that can be used to make conjugates with carbonyl-containing molecules. Biotin PEG4 amine has a water-soluble and flexible spacer arm that helps to reduce aggregation and steric hindrance.


Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Biotin PEG4 amine to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

0.1 mg0.5 mg1 mg5 mg10 mg
1 mM238.92 µL1.195 mL2.389 mL11.946 mL23.892 mL
5 mM47.784 µL238.92 µL477.84 µL2.389 mL4.778 mL
10 mM23.892 µL119.46 µL238.92 µL1.195 mL2.389 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)Molecular weightVolume (Calculate)Concentration (Calculate)Moles



View all 11 references: Citation Explorer
Discovery of two biotin-PEG4‑diarylidenyl piperidone prodrugs as potent antitumor agents with good efficacy, limited toxicity, and low resistance.
Authors: Liu, Shuang-Qiang and Mao, Zhi-Chen and Xu, Yan-Li and Chen, Xiao-Man and Wang, Hui-Ling and Wang, Qi and Wei, Jian-Hua and Huang, Ri-Zhen and Zhang, Ye
Journal: Bioorganic chemistry (2023): 106323
Highly Selective Electrochemical Detection of 5-Formyluracil Relying on (2-Benzimidazolyl) Acetonitrile Labeling.
Authors: Tang, Jing and Zou, Guangrong and Chen, Chen and Ren, Jing and Wang, Fang and Chen, Zilin
Journal: Analytical chemistry (2021): 16439-16446
Targeted Association and Intracellular Delivery of Nanocargoes into Primary T Lymphocytes via Interleukin-2 Receptor-Mediated Endocytosis.
Authors: Ayyadevara, V S S Abhinav and Ahmadi, Armin and Roh, Kyung-Ho
Journal: Bioconjugate chemistry (2021): 1675-1687
Synthesis of 3'-O-Alkyl Homologues and a Biotin Probe of Isorhamnetin and Evaluation of Cytotoxic Efficacy on Cancer Cells.
Authors: Yang, Zhuojin and Zheng, Yi and Tursumamat, Nafisa and Zhu, Mingyan
Journal: Chemistry & biodiversity (2021): e2100301
Differential biotin labelling of the cell envelope proteins in lipopolysaccharidic diderm bacteria: Exploring the proteosurfaceome of Escherichia coli using sulfo-NHS-SS-biotin and sulfo-NHS-PEG4-bismannose-SS-biotin.
Authors: Monteiro, Ricardo and Chafsey, Ingrid and Leroy, Sabine and Chambon, Christophe and Hébraud, Michel and Livrelli, Valérie and Pizza, Mariagrazia and Pezzicoli, Alfredo and Desvaux, Mickaël
Journal: Journal of proteomics (2018): 16-23
A cleavable biotin tagging reagent that enables the enrichment and identification of carbonylation sites in proteins.
Authors: Coffey, Chelsea M and Gronert, Scott
Journal: Analytical and bioanalytical chemistry (2016): 865-74
Focal calcium monitoring with targeted nanosensors at the cytosolic side of endoplasmic reticulum.
Authors: Hou, Yanyan and Arai, Satoshi and Takei, Yoshiaki and Murata, Atsushi and Takeoka, Shinji and Suzuki, Madoka
Journal: Science and technology of advanced materials (2016): 293-299
SPECT/NIRF Dual Modality Imaging for Detection of Intraperitoneal Colon Tumor with an Avidin/Biotin Pretargeting System.
Authors: Dong, Chengyan and Yang, Sujuan and Shi, Jiyun and Zhao, Huiyun and Zhong, Lijun and Liu, Zhaofei and Jia, Bing and Wang, Fan
Journal: Scientific reports (2016): 18905
Mussel-inspired new approach for polymerization and cross-linking of peptides and proteins containing tyrosines by Fremy's salt oxidation.
Authors: Wilchek, Meir and Miron, Talia
Journal: Bioconjugate chemistry (2015): 502-10
Smart tools and orthogonal click-like reactions onto small unilamellar vesicles.
Authors: Salomé, Christophe and Spanedda, Maria Vittoria and Hilbold, Benoit and Berner, Etienne and Heurtault, Béatrice and Fournel, Sylvie and Frisch, Benoit and Bourel-Bonnet, Line
Journal: Chemistry and physics of lipids (2015): 27-36