Biotin PEG4 amine

Biotin PEG4 amine is a biotinylation reagent with a PEG4 spacer. It is an excellent building block that can be used to make conjugates with carbonyl-containing molecules. Biotin PEG4 amine has a water-soluble and flexible spacer arm that helps to reduce aggregation and steric hindrance.

Protocol

SDS

COO

COA

Catalog	Size	Price	Quantity
3013	5 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of Biotin PEG4 amine to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	216.165 µL	1.081 mL	2.162 mL	10.808 mL	21.616 mL
5 mM	43.233 µL	216.165 µL	432.33 µL	2.162 mL	4.323 mL
10 mM	21.616 µL	108.082 µL	216.165 µL	1.081 mL	2.162 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	462.61 g/mol	=	mL	x	mM	=	mmol

References

View all 11 references: Citation Explorer

Discovery of two biotin-PEG4‑diarylidenyl piperidone prodrugs as potent antitumor agents with good efficacy, limited toxicity, and low resistance.

Authors:

Liu, Shuang-Qiang and Mao, Zhi-Chen and Xu, Yan-Li and Chen, Xiao-Man and Wang, Hui-Ling and Wang, Qi and Wei, Jian-Hua and Huang, Ri-Zhen and Zhang, Ye

Journal:

Bioorganic chemistry (2023): 106323

Highly Selective Electrochemical Detection of 5-Formyluracil Relying on (2-Benzimidazolyl) Acetonitrile Labeling.

Authors:

Tang, Jing and Zou, Guangrong and Chen, Chen and Ren, Jing and Wang, Fang and Chen, Zilin

Journal:

Analytical chemistry (2021): 16439-16446

Targeted Association and Intracellular Delivery of Nanocargoes into Primary T Lymphocytes via Interleukin-2 Receptor-Mediated Endocytosis.

Authors:

Ayyadevara, V S S Abhinav and Ahmadi, Armin and Roh, Kyung-Ho

Journal:

Bioconjugate chemistry (2021): 1675-1687

Synthesis of 3'-O-Alkyl Homologues and a Biotin Probe of Isorhamnetin and Evaluation of Cytotoxic Efficacy on Cancer Cells.

Authors:

Yang, Zhuojin and Zheng, Yi and Tursumamat, Nafisa and Zhu, Mingyan

Journal:

Chemistry & biodiversity (2021): e2100301

Differential biotin labelling of the cell envelope proteins in lipopolysaccharidic diderm bacteria: Exploring the proteosurfaceome of Escherichia coli using sulfo-NHS-SS-biotin and sulfo-NHS-PEG4-bismannose-SS-biotin.

Authors:

Monteiro, Ricardo and Chafsey, Ingrid and Leroy, Sabine and Chambon, Christophe and Hébraud, Michel and Livrelli, Valérie and Pizza, Mariagrazia and Pezzicoli, Alfredo and Desvaux, Mickaël

Journal:

Journal of proteomics (2018): 16-23

Physical properties

Molecular weight	462.61
Solvent	DMSO

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
CAS	663171-32-2

Documents

Protocol
Safety Data Sheet
Certificate of Origin
Certificate of Analysis

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Page updated on November 21, 2025