FITC Anti-non-human primates/ human CD35 Antibody *E11*

E11 is an anti-non-human primates/ human monoclonal antibody that recognizes the CD35 antigen. CD35 (alternatively called Complement receptor type 1) is a single-pass type I membrane protein that is found on the surface of cells such as erythrocytes. CD35 plays a role in key cellular pathways, for example, the negative regulation of complement activation, alternative pathway and complement activation, classical pathway. Moreover, in certain organisms, it represses serine-type endopeptidase activity, plays a role in the downregulation of complement activation, alternative pathway and is involved in the positive regulation of serine-type endopeptidase activity. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as ic3, c4b, c3b and ic4. CD35 is a fairly uncommon antibody target, with a little more than 1800 publications in the last decade. Even still, CD35 has been widely used in immunology, cell biology and neuroinflammation research, commonly serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to FITC (ex/em = 491/516 nm). It is compatible with the 488 nm laser and 525/45 nm bandpass filter (for example, as in the Agilent Technologies NovoCyte Advanteon).

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