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FITC–dextran conjugate (average MW = ~70K)

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Physical properties
Molecular weight~ 70,000
Spectral properties
Correction Factor (280 nm)0.35
Extinction coefficient (cm -1 M -1)73000
Excitation (nm)491
Emission (nm)516
Quantum yield0.92
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure


Molecular weight
~ 70,000
Correction Factor (280 nm)
Extinction coefficient (cm -1 M -1)
Excitation (nm)
Emission (nm)
Quantum yield
FITC-labeled dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. It is also used in microcirculation and cell permeability research utilizing microfluorimetry, and possible in perfusion studies in animals. FITC-dextran has also been used to study plant cell wall porosity and capillary permeability. Plasma proteins have been shown not to bind to FITC-dextran. FITC-dextran of ~70 kDa may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. It may be used in microvascular and cell monolayer permeability studies.


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Spectral properties

Correction Factor (280 nm)0.35
Extinction coefficient (cm -1 M -1)73000
Excitation (nm)491
Emission (nm)516
Quantum yield0.92

Product Family

NameExcitation (nm)Emission (nm)Extinction coefficient (cm -1 M -1)Quantum yieldCorrection Factor (280 nm)
FITC–dextran conjugate (average MW = ~20K)491516730000.920.35
FITC–dextran conjugate (average MW = ~150K)491516730000.920.35
TRITC–dextran conjugate (average MW = ~70K)544570100000-0.34



View all 43 citations: Citation Explorer
Lymphatic Reconnection and Restoration of Lymphatic Flow by Nonvascularized Lymph Node Transplantation: Real-Time Fluorescence Imaging Using Indocyanine Green and Fluorescein Isothiocyanate-Dextran
Authors: Maeda, T., Yamamoto, Y., Iwasaki, D., Hayashi, T., Funayama, E., Oyama, A., Murao, N., Furukawa, H.
Journal: Lymphat Res Biol (2018): 165-173
Optimizing Fluorescein Isothiocyanate Dextran Measurement As a Biomarker in a 24-h Feed Restriction Model to Induce Gut Permeability in Broiler Chickens
Authors: Baxter, M. F. A., Merino-Guzman, R., Latorre, J. D., Mahaffey, B. D., Yang, Y., Teague, K. D., Graham, L. E., Wolfenden, A. D., Hern and ez-Velasco, X., Bielke, L. R., Hargis, B. M., Tellez, G.
Journal: Front Vet Sci (2017): 56
Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability
Authors: Natarajan, R., Northrop, N., Yamamoto, B.
Journal: Curr Protoc Neurosci (2017): 9 58 1-9 58 15
Adenosine receptor agonist NECA increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation
Authors: Cheng, C. C., Yang, Y. L., Liao, K. H., Lai, T. W.
Journal: Sci Rep (2016): 23882
Analysis of hair follicle penetration of lidocaine and fluorescein isothiocyanate-dextran 4 kDa using hair follicle-plugging method
Authors: Horita, D., Yoshimoto, M., Todo, H., Sugibayashi, K.
Journal: Drug Dev Ind Pharm (2014): 345-51
Fluorescein-dextran sequestration in the reproductive tract of the migratory grasshopper Melanoplus sanguinipes (Orthoptera, Acridiidae)
Authors: Jones, N., Taub-Montemayor, T., Rankin, M. A.
Journal: Micron (2013): 80-4
Evaluation of changes in hepatic disposition of phenolsulfonphthalein, indocyanine green and fluorescein isothiocyanate-dextran at low temperatures using a rat liver perfusion system
Authors: Miyamoto, H., Miyake, H., Yoshikawa, N., Hirata, H., Ohwaki, Y., Fumoto, S., Sasaki, H., Nakamura, J., Nishida, K.
Journal: J Pharm Pharmacol (2012): 848-54
Effects of vitreous liquefaction on the intravitreal distribution of sodium fluorescein, fluorescein dextran, and fluorescent microparticles
Authors: Tan, L. E., Orilla, W., Hughes, P. M., Tsai, S., Burke, J. A., Wilson, C. G.
Journal: Invest Ophthalmol Vis Sci (2011): 1111-8
Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran
Authors: Clanton, J. A., Shestopalov, I., Chen, J. K., Gamse, J. T.
Journal: J Vis Exp (2011): se name="21700.enl" path="C:\Users\aatbi\Drop
A method for assessment of blood volume parameters in pregnant sheep using fluorescein-labelled dextran
Authors: Rumball, C. W., Van Zijl, P., Rutl and , M. D., Bloomfield, F. H., Harding, J. E.
Journal: Placenta (2008): 15-9