iFluor® 405 Anti-human CD109 Antibody *W7C5*

The W7C5 monoclonal antibody binds with human CD109, a 162 kD transmembrane protein typically expressed on the surface of T cells and T cell lines. CD109 acts in essential cellular pathways, for instance, the negative regulation of transforming growth factor beta receptor signaling pathway. Additionally, in some organisms, it is a suppressor of transforming growth factor beta receptor signaling pathway, is a repressor of wound healing and is a repressor of keratinocyte proliferation. From a research standpoint, it is of biological interest due to its association with critical macromolecules/ligands. CD109 is a relatively rare antibody target, with fewer than 600 publications in the last decade. Even still, CD109 is vital to immunology research, frequently serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to iFluor® 405 (ex/em = 403/427 nm). It is compatible with the 405 nm laser and 450/50 nm bandpass filter (for example, as in the BD FACSCanto™).

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