iFluor® 430 Anti-human CD11a Antibody *HI111*

HI111 is an anti-human monoclonal antibody that forms an immune complex with the CD11a antigen. CD11a (also known as Integrin alpha-L or LFA-1α chain) is a 170 - 180 kD transmembrane protein that is expressed on the surface of cells such as granulocytes and macrophages. CD11a has been associated with critical biological processes like cell-cell adhesion, especially leukocyte cell-cell adhesion. Moreover, it is a member of essential cellular pathways, for instance, the integrin-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands such as CD18 and ICAM-1, 2, 3 and 4. CD11a is a fairly uncommon antibody target, with a little more than 3700 publications in the last decade. Even still, CD11a has a variety of applications in neuroscience and innate immunity research, typically serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to iFluor® 430 (ex/em = 433/498 nm). It is compatible with the 445 nm laser and 510/80 nm bandpass filter (for example, as in the BD FACSAria™ Fusion).