iFluor® 430 Anti-human/ rabbit/ cat/ non-human primates/ ferret CD271 Antibody *NGFR5*

NGFR5 is an anti-human/ rabbit/ cat/ non-human primates/ ferret monoclonal antibody that is specific for the CD271 antigen. CD271 (sometimes referred to as TNFRSF16 or Gp80-LNGFR) is a 75 kD transmembrane protein that is found on the surface of cells like dendritic cells. CD271 is a component of important cellular pathways, namely, the neurotrophin TRK receptor signaling pathway, negative regulation of fibroblast growth factor receptor signaling pathway and positive regulation of apoptotic signaling pathway. Also, it has been associated with critical biological processes like glucose homeostasis, especially cellular glucose homeostasis. In certain organisms, CD271 plays a role in the upregulation of pri-miRNA transcription by RNA polymerase II, positively regulates apoptotic process and is a negative regulator of hair follicle development. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands like NT-3 and NT-4. CD271 is a fairly uncommon antibody target, with a little more than 1700 publications in the last decade. Even still, CD271 is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, especially in the study of stem cells, immunology and neuroscience. This antibody was purified through affinity chromatography and conjugated to iFluor® 430 (ex/em = 433/498 nm). It is compatible with the 445 nm laser and 510/80 nm bandpass filter (for example, as in the BD FACSAria™ III).

Page updated on September 2, 2025