Products
Services
Resources
Selection Guides
About
iFluor® 488 Anti-human CD11b Antibody
HI11b
HI11b is an anti-human monoclonal antibody that recognizes the CD11b antigen. CD11b (sometimes referred to as Integrin αM chain, C3biR, CR3A or CR3) is a 165 - 170 kD glycoprotein that is expressed on the surface of cells such as B cells, granulocytes, NK cells, macrophages and dendritic cells. CD11b is involved with important cellular pathways, in particular, the cytokine-mediated signaling pathway, toll-like receptor 4 signaling pathway and apoptotic signaling pathway. Additionally, in many organisms, it is a promoter of superoxide anion generation, positively regulates microglial cell mediated cytotoxicity and is a positive regulator of prostaglandin-E synthase activity. CD11b has been associated with critical biological processes like cell adhesion, specifically cell-cell adhesion via plasma-membrane adhesion molecules, and is associated with a variety of biologically interesting macromolecules/ligands, for example, Factor X, iC3b and ICAM-1. CD11b is a very popular antibody target, with over 45000 publications in the last decade. CD11b has been widely used in innate immunity, neuroscience cell markers and cell biology research, often serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to iFluor® 488 (ex/em = 491/516 nm). It is compatible with the 488 nm laser and 509/24 nm bandpass filter (for example, as in the Bio-Rad ZE5 Cell Analyzer).
| Catalog | Size | Price | Quantity |
|---|---|---|---|
| 10111050 | 100 tests | Price | |
| 10111051 | 500 tests | Price |
Physical properties
| Molecular weight | N/A |
| Solvent | water |
Antibody properties
| Other names | CR3, Mac-1, Mo1, ITGAM, Integrin alpha-M |
| Clone | HI11b |
| Host | Mouse |
| Isotype | IgG2b |
| Reactivity | Human |
| Application | Flow Cytometry (FACS), Fluorescence Imaging |
Spectral properties
| Correction factor (260 nm) | 0.21 |
| Correction factor (280 nm) | 0.11 |
| Extinction coefficient (cm -1 M -1) | 75000 1 |
| Excitation (nm) | 491 |
| Emission (nm) | 516 |
| Quantum yield | 0.9 1 |
Usage and storage
| Intended use | Research Use Only (RUO) |
| Storage | Refrigerated (2-8 °C); Minimize light exposure |
Contact us
| Telephone | |
| Fax | |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Technical Support | Contact us |
| Request quotation | Request |
| Purchase order | Send to sales@aatbio.com |
| Shipping | Standard overnight for United States, inquire for international |
Page updated on August 1, 2026